CORDIS Project
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This project investigates the stability of human centromeres, which are crucial for proper cell division. By employing innovative techniques, it aims to understand how centromere dysfunction contributes to cancer and aging, focusing on the role of specific proteins in maintaining DNA stability.
Cell division relies on centromeres, which connect chromosomes to the spindle for separating sister chromatids in mitosis.
Human centromeres are composed of large arrays of repetitive DNA, which are often sites of aberrant rearrangements in cancer.
While centromere defects can cause chromosomal instability, the molecular mechanisms that maintain their repetitive DNA stable are poorly understood.
During the fellowship, I aim to investigate how human centromere stability is maintained and the cons…
UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA
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