CORDIS Project
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This project investigates the molecular mechanisms of protein degradation by the Lon protease in Escherichia coli. It aims to enhance understanding of how this enzyme processes damaged proteins, which is crucial for cellular health and has implications for diseases linked to protein misfolding.
Background:
AAA+ proteases are ubiquitous molecular machines that execute regulated protein degradation in cells.
Their activity is necessary for regulation of many cellular processes, as well as to clear the cell of misfolded, potentially harmful proteins.
Failure to combat protein unfolding in unicellular organisms often leads to reduced viability, and in humans, accumulation of misfolded proteins may result in prion diseases, cancer and neurodegenerative disorders.
Conserved in bacteria and e…
BEN-GURION UNIVERSITY OF THE NEGEV
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