CORDIS Project
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This project aims to clarify the enzymatic mechanism of Type II topoisomerase, an important enzyme in DNA processes, and to identify new inhibitors for potential use in antibiotics and cancer therapies. It employs advanced computational methods to understand metal ion dynamics in enzyme catalysis.
Type II topoisomerase (TopoII) metalloenzymes are crucial in regulating DNA topology in replication, transcription, recombination, and repair processes.
TopoII is thus a validated target for clinical antibiotics and anticancer drugs.
Recent high-resolution X-ray structures of the TopoII/DNA complex showed multiple metal ions bound to the TopoII active site.
On the basis of these novel findings, a unified two-metal-ion reaction mechanism for TopoII catalysis has been proposed.
However, it is stil…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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