CORDIS Project
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This project investigates the role of ATR kinase in maintaining genome integrity, particularly its response to mechanical forces and its translocation to the nuclear envelope. Using advanced imaging and molecular techniques in the Xenopus laevis model, the research aims to uncover the mechanisms of ATR activation and i…
ATR kinase is involved in maintaining genome integrity by ensuring replication fork stability and coordinating cell cycle progression with the DNA repair. ATR is a developmentally essential gene and in humans and hypomorphic mutations in ATR gene have been linked to Seckel syndrome characterized by mental and growth retardation and microcephaly.
While the role of ATR in mediating DNA damage response has been extensively studied, the findings that it senses mechanical forces and translocates to t…
UNIVERSITY OF CYPRUS
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