CORDIS Project
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This project investigates the mechanical properties of immune cells to improve adoptive cell transfer therapies for solid tumors. By enhancing the sensitivity of cytotoxic lymphocytes to mechanical cues, the research aims to overcome resistance in cancer treatment, potentially transforming immunotherapy approaches.
Adoptive cell transfer (ACT) with cytotoxic lymphocytes, including chimeric antigen receptor (CAR)-T cells, is a powerful immunotherapy already demonstrating remarkable success against certain blood cancers.
However, its efficacy in treating solid tumors remains limited, with durable responses being rare.
Current strategies to improve ACT therapy focus predominantly on biochemical interactions between immune cells and cancer cells.
Yet, emerging evidence highlights the significant influence of b…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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