CORDIS Project
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The MechanoMVP project investigates the genetic and mechanistic factors contributing to mitral valve prolapse, a common heart condition. By studying a unique rat model, the project aims to uncover potential therapeutic targets to address this condition and its related health impacts.
Mitral valve prolapse (MVP) is the most frequent form of degenerative mitral valve (MV) disease and is a major cause of cardiovascular morbidity and mortality.
No medical therapy is currently available.
Familial and population genetic studies have identified genes causally related to non-syndromic MVP, such as FLNA, encoding for Filamin A protein.
These findings have paved the road to study mechanisms and signaling pathways involved in the development and progression of MVP that will then be use…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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