CORDIS Project
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This project investigates the activation mechanism of the MCM helicase, crucial for DNA replication. By analyzing the interactions between helicase and firing factors, it aims to understand how the helicase transitions from an inactive to an active state, which is vital for genome duplication and has implications for c…
The initiation of DNA replication requires dynamic biomolecular interactions, which are temporally and spatially regulated to allow genome duplication only once per cell cycle.
During eukaryotic replication initiation, the MCM helicase is loaded as an inactive double hexamer encircling double-stranded DNA (dsDNA).
It is activated by a set of proteins called firing factors in a kinase-dependent manner, thereby forming the CMG complex (Cdc45, MCM, GINS), which encircles single-stranded DNA (ssDNA)…
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