CORDIS Project
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This project investigates how mechanical forces influence the development of joint shapes during embryonic growth, particularly in relation to conditions like Developmental Dysplasia of the Hip. By studying mutant mouse embryos, it aims to understand joint morphogenesis and develop techniques to promote cartilage growt…
Most joints start off the same during embryonic development, as two opposing cartilage surfaces, and are moulded into the diverse range of shapes seen in the adult in a process known as morphogenesis.
While we understand very little of the biological or mechanobiological processes driving joint morphogenesis, there is evidence to suggest that fetal movements play a critical role in joint shape development.
Developmental Dysplasia of the Hip (DDH), where the hip is partly or fully dislocated, is…
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