CORDIS Project
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This project investigates how cancer cells transition from an epithelial to a mesenchymal state using mechanical processes. By studying these mechanisms in zebrafish embryos, the research aims to enhance understanding of cancer metastasis and potential treatment strategies.
While cancer biologists have long assumed that developmental Epithelial to Mesenchymal Transitions (EMT) transcriptional programs also control cancer metastasis, our lab has recently found that cancer EMT instead uses a mechanical-based two-step process.
Typically, epithelial cells fated to die get extruded apically into the lumen.
However, oncogenic mutations that drive metastatic cancers hijack this process, causing cells to either form masses or to extrude basally back into the tissue at sepa…
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