CORDIS Project
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This project explores the molecular mechanisms of Wnt signaling, which is crucial for cell growth and development. By using advanced imaging and biochemical techniques, the research aims to clarify how Wnt proteins initiate signaling pathways that can lead to cancer.
Wnt proteins dictate critical cell growth and lineage decisions during development and in adult tissue homeostasis.
Inappropriate activation of Wnt signalling is a frequent cause of cancer.
The earliest events that occur after Wnts bind their receptors at the cell surface, such as receptor endocytosis and recruitment of cytoplasmic effectors, are decisive for downstream gene activation but the underlying mechanisms by which these events process and tune the Wnt signal remain poorly understood. T…
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
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