CORDIS Project

Anticancer approach based on the Metabolic Disruption of Cancer Stem Cells with high effectivity across a wide range of solid tumours

MEDiCS·101214053·HORIZON

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View on CORDIS DOI grant

Funding data

Programme: Horizon Europe
Participants: 4
Start - End: 01/05/2025 — 30/04/2028
Status: SIGNED

Summary

This project investigates the anticancer properties of the ruthenium complex IGN116, which targets cancer stem cells by disrupting their energy production. It aims to develop this compound for treating colorectal and pancreatic cancers, focusing on minimizing toxicity while maximizing efficacy.

Objective

By combining advanced synthetic chemistry with cancer biology, we have demonstrated the potential of ruthenium complex IGN116 as an effective and tolerable anticancer agent, inhibiting tumour proliferation as early as 1-2 days post treatment in pre-clinical PDX models.

Instead of acting as a cytotoxic agent, IGN116 interferes with the key bioenergetic pathway (aerobic oxidative phosphorylation) utilized by Cancer Stem Cells (CSC), drastically effecting their stemness potential whilst keeping oth…

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Coordinator

UNIVERSIDADE DE SANTIAGO DE COMPOSTELA

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA

Country: Spain, Santiago De Compostela
Organization type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No

Network and participants(4 participants)

Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.

I3S - INSTITUTO DE INVESTIGACAO E INOVACAO EM SAUDE DA UNIVERSIDADE DO PORTO
Portugal, PORTO
Type: Research institute
Activity type: Research Organisations
SME: No
participant
UAM
Spain, Madrid
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
participant
MyB
Germany, UBERHERRN
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
participant
ASPHALION
Spain, Barcelona
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
participant

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CORDIS call / funding scheme

Programme: HORIZON
Call: HORIZON-EIC-2024-TRANSITION-01
Sub call: HORIZON-EIC-2024-TRANSITION-01
Funding scheme: HORIZON-EIC
Domain note: This block describes the CORDIS project call context. Live open opportunities are managed in the Funding & Tenders domain.

Fields of Science (EuroSciVoc)

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Medical and health sciencesClinical medicineOncology
Natural sciencesChemical sciencesInorganic chemistryTransition metals

Topic

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HORIZON-EIC-2024-TRANSITIONOPEN-01

Keywords

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Cancer stem cells Anticancer agents Metal-based therapeutics Colorectal Cancer Pancreatic Cancer