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MEGFIB aims to develop RNA-based therapies targeting cardiac fibrosis in heart failure patients. By silencing specific noncoding RNAs, the project seeks to improve heart function and advance these findings towards commercial viability.
Cardiac fibrosis is a hallmark of and mechanistically involved in heart failure; a disease will high clinical unmet need and fundamental socioeconomic importance.
Specific treatments of cardiac fibrosis are lacking. RNAs that do not code for proteins comprise a large portion of the human genome.
These so-called noncoding RNAs are emerging as important players in disease pathogenesis, yet their functional roles are ill understood.
Our group currently pioneered first clinical testings on noncoding…
MEDIZINISCHE HOCHSCHULE HANNOVER
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