CORDIS Project
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This project explores the functions of the LRRK2 protein, which is linked to Parkinson's Disease, in pigmented melanoma cells. By using gene editing techniques, it aims to identify LRRK2's substrates and its role in melanin production and neuronal health.
LRRK2 is a multi-domain protein, which uniquely possesses both protein kinase and GTPase catalytic activities.
Autosomal dominant mutations of LRRK2 represent one of the principal genetic risk factors for Parkinson’s Disease (PD), which results in preferential loss of neuromelanin containing, dopaminergic neurons from the substantia nigra.
The (patho)physiological roles of LRRK2 are currently unclear.
However, it has been linked to the regulation of endolysosmal membrane trafficking through comp…
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