CORDIS Project
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This project investigates the role of melanosomes in melanoma immunity, focusing on their interactions with T-cells and macrophages. By exploring these mechanisms, the research aims to identify new therapeutic strategies to overcome resistance to melanoma treatments.
Despite remarkable progress in treating melanoma, the most lethal of human skin cancers, 50% of patients are treatment-resistant, with most experiencing disease recurrence.
Our recent unpublished clinical and experimental findings uncover new, yet to be explored, melanosome contributions to cancer immunity unique to melanoma.
Melanoma retains, for mostly unknown reasons, the ability of its origin to produce melanosomes, lineage-specific large extracellular vesicles (EVs) containing melanin.
Surp…
TEL AVIV UNIVERSITY
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