CORDIS Project
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This project investigates how human memory Natural Killer cells develop and maintain their ability to respond to pathogens, focusing on the signals and mechanisms that influence their clonal memory. By utilizing advanced techniques, the research aims to uncover insights that could lead to improved anti-tumor therapies.
The pool of innate immune effector cells is wired to rapidly respond to pathogens, whereas only few specificities within the nave adaptive repertoire expand clonally, undergo epigenetic remodelling and differentiate into effector and memory cells.
However, innate cells can differentiate upon pathogen encounter and remember past experiences as well, thereby challenging this strict dichotomy.
In particular, us and others have shown that human memory Natural Killer (NK) cells with global epigenetic…
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