CORDIS Project
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This project investigates the mechanisms of membrane abscission, focusing on the ESCRT-III protein complex involved in processes like cell division and viral budding. By exploring the assembly and function of these proteins, the research aims to uncover new therapeutic targets for diseases linked to these cellular proc…
Cellular processes such as cytokinesis, the budding of enveloped retrovirus (e.g. HIV-1), and multivesicular biogenesis have direct links to several human diseases including carcinogenesis and neuro-degeration etc.
While seemingly unrelated, these processes all involve membrane abscission for generating two newly formed membrane bound structures - a process aided by the cytosolic proteins collectively termed ESCRT-III.
Understanding these processes for therapeutic intervention has so far focused…
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