CORDIS Project
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This project aims to understand how immune system proteins and pathogens use membrane pore-forming proteins to disrupt cell membranes. It employs advanced imaging techniques to visualize the interactions between immune cells and pathogens, focusing on the dynamics of these processes.
The immune system and pathogens both use membrane pore-forming proteins to penetrate cellular membranes, in order to kill target cells or to allow passage of pathogenic organisms such as malaria parasites, listeria, or toxoplasma.
For both fundamental and practical reasons, it is important to understand the biological actions of the ""arms race"" underlying virulence, pathogenesis and immune defense.
The key weapon in this membrane attack is a class of proteins that upon activation undergo a dra…
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