CORDIS Project
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This project investigates how local protein synthesis at synapses contributes to memory formation in the brain. By employing advanced imaging and sequencing techniques, it aims to decode the molecular mechanisms underlying memory storage and enhance our understanding of synaptic function, with implications for neurodeg…
Despite their role in long-term information storage, synapses are highly dynamic and composed of rather short-lived components.
In the adult mouse brain, it takes a couple of days for half dendritic spines to be replaced.
Similarly at the molecular level most synaptic proteins have half-lives in the order of a week meaning they constantly need to be replaced by freshly produced ones.
Thus, understanding how long-term memory can arise from unstable elements is one of todays neurosciences greatest…
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