CORDIS Project
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This project investigates how rats can learn and retain multiple sounds over time, focusing on the stability of these memories. It explores the neural mechanisms behind memory acquisition and consolidation, particularly in a model for Alzheimer's disease.
How much can we remember and for how long?
Decades of key advances in our understanding of synaptic plasticity resulted in a puzzle.
On the one hand, memories can be highly stable and organisms are capable of adding new memories without destroying old ones.
On the other hand, data and models support neither stability nor lifelong (‘continual’) learning.
Many experiments suggest that responses of neuronal populations slowly but inexorably drift (“representational drift”), while synapses spontaneo…
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