CORDIS Project
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The MEMORIS project investigates how maternal gut microbes influence the immune development and disease susceptibility of offspring. By studying germ-free mice, the project aims to understand the long-term effects of maternal microbial signals on the offspring's immune system and microbiota composition.
Recently, it has emerged that early life exposure to commensal microbes is crucial to instruct our immune system and prevent later life autoimmune and metabolic diseases.
The host lab now showed that this education begins even earlier – during gestation by signals from the maternal intestinal microbiota.
Using the E. coli strain HA 107, genetically engineered to grow in vitro without the ability to persist in vivo, they demonstrated that transient intestinal colonisation of pregnant germ-free mo…
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