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The MemOriStem project investigates the origins and mechanisms of hematopoietic stem cell memories, which influence blood cell production and functionality. By utilizing innovative mouse models and molecular techniques, it aims to enhance understanding of stem cell behavior, with potential applications in regenerative…
Hematopoiesis has long been modeled as a stepwise hierarchical process, where all blood cells arise from a single group of rare multipotent stem cells.
For decades, various reports have contested this unifying paradigm, indicating that hematopoietic stem cells are functionally heterogeneous and differ on the rates and types of blood cells that they produce.
However, the origins of stem cell heterogeneity and, importantly, its physiological consequences have remained ambiguous.
My recent research…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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