CORDIS Project
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This project investigates how yeast cells control the aggregation of a specific protein, Whi3, which is crucial for adapting to environmental changes. By examining the factors influencing this process, the research aims to understand the link between protein aggregation and age-related neurodegenerative diseases.
Age-associated neurodegenerative diseases are characterised by the irreversible pathological aggregation of proteins with low complexity (LC) sequences.
In contrast, cells can exploit LC protein aggregation to help them adapt to changing environments.
The factors that determine whether an aggregate is functional or pathological are unclear.
How do cells control protein aggregation?
Are age-associated diseases caused by loss of control over functional protein aggregates?
To address these question…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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