CORDIS Project
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This research examines how the mTOR pathway influences the behavior of regulatory T cells, which are crucial for immune tolerance. The project aims to clarify the relationship between metabolism and T cell responsiveness, with implications for understanding autoimmune diseases.
Our group has been investigating how the nutrient/energy-sensing mammalian target of rapamycin (mTOR)-pathway affects the responsiveness of CD4+CD25+FoxP3+ regulatory T cells (Tregs).
We have shown that Tregs have a high metabolic profile associated with the hyperactivation of the mTOR-pathway, which is responsible for the in vitro anergy of these cells. A transient mTOR inhibition with rapamycin, before T-cell-receptor (TCR)-stimulation, induced Tregs proliferation in the absence of exogenous i…
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