CORDIS Project
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This project investigates how mechanical load affects cardiac function by studying the interaction between the sarcomere and spliceosome. It aims to understand the role of splice factors in regulating heart muscle elasticity and their implications for heart disease, particularly in conditions like cardiomyopathy and he…
To adapt cardiac function in response to mechanical load, a network of splice factors concertedly regulates multiple target mRNAs that affect biomechanics, electrical activity, metabolism, signaling, and growth.
It includes the splice regulator RBM20, with mutations causing severe cardiomyopathy, as well as its substrate titin, whose >350 exons are differentially joined to adjust the elastic properties of the sarcomere and thus ventricular filling.
In the spliceosome, diverse RNAs and RNA bindin…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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