CORDIS Project
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This research focuses on regenerating insulin-producing cells in the pancreas to combat diabetes. By reprogramming other cell types and studying metabolic adaptations, the project aims to understand and enhance insulin secretion in response to glucose levels.
My group aims at fostering the regeneration of insulin-producing -cells in the diabetic pancreas by promoting the reprogramming of other islet endocrine non- cells. I will use mice and human islets to trigger the metabolic reprogramming of: i) peripheral organs, in order to reduce hyperglycemia, and ii) human islet non--cells, to induce their acquisition of insulin secretion.I developed transgenics to elicit total (>99%) or graded (5-90%) -cell loss.
These mice revealed that non--cells, which pr…
UNIVERSITE DE GENEVE
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