CORDIS Project
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This project investigates how cancer driver mutations in the endometrium affect the immune environment and contribute to endometriosis development. By analyzing menstrual fluid and creating a mouse model, it aims to enhance understanding of the disease and develop new diagnostic and treatment strategies.
Endometriosis is characterized by the presence of endometrium-like tissue outside the uterus and chronic inflammation.
Worldwide, >10% of reproductive-age women suffer from pain and/or infertility caused by this disease.
Recently, cancer driver mutations have been identified in both the eutopic and ectopic endometrium of endometriosis patients.
Moreover, it has been shown in cancer studies that cancer driver mutations can alter the local immune microenvironment.
Nevertheless, it has never been s…
STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
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