CORDIS Project
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This project develops a new analytical platform for studying single-cell metabolomics using the yeast Saccharomyces cerevisiae. By employing microfluidic processing and high-sensitivity mass spectrometry, it aims to provide insights into cellular metabolism and variability, enhancing our understanding of cellular funct…
We propose to develop an analytical platform for single-cell metabolomics and apply it in fundamental studies carried out on a model eukaryotic organism, Saccharomyces cerevisiae.
Due to the minute amounts of metabolites present in each cell, almost all current methods used in biochemistry and molecular biology provide data that are averaged over an entire cell population while even cells in monoclonal cultures display profound variations on all physiological levels.
This approach to molecular b…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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