CORDIS Project
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The MesHH study investigates the effectiveness of DNA methylation markers and HPV DNA for detecting high-grade cervical lesions in women living with HIV in Burkina Faso and South Africa. By comparing these methods to traditional screening techniques, the project aims to improve specificity and reduce unnecessary treatm…
Background:
The current screening methods for cervical cancer screening among women living with HIV (WLHIV) have previously shown high sensitivity but poor specificity for the detection of high-grade cervical intraepithelial neoplasia (CIN2+), resulting in over-referral for colposcopy and overtreatment of cervical lesions that may have low potential for progression to cancer.
Methylation changes of human genes or HPV DNA have been reported early in carcinogenesis but their validation for predict…
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
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