CORDIS Project
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This project investigates the role of inhibitory circuits in the mesocorticolimbic system related to reward learning and addiction. It aims to understand how these circuits change with drug exposure and their implications for behavior.
The mesocorticolimbic (MCL) system, extending from the ventral tegmental area (VTA) to the nucleus accumbens and prefrontal cortex, comprises a dopamine (DA) projection implicated in reinforcement learning.
The MCL system is the target of addictive substances and of drug-evoked synaptic plasticity, a cellular mechanism that may underlie the adaptive, pathological behaviors that occur after repeated drug exposure.
While most previous work has focused on excitatory transmission, recent studies sug…
UNIVERSITE DE GENEVE
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