CORDIS Project
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This project investigates the role of D-type Cyclins in DNA replication and cell cycle regulation, particularly how their deregulation can lead to cancer. It aims to identify metabolic signatures and molecular mechanisms that influence DNA synthesis speed and stability.
Faithful eucaryotic cell division requires spatio-temporal orchestration of multiple sequential events.
Among the crucial steps to providing the daughter cells with identical set of chromosomes is the DNA replication.
During this phase, cells coordinate the speed of DNA synthesis with the length of the cell cycle to ensure genome integrity.
To do so, growth factors and metabolic signals are integrated primarily by D-type Cyclins.
Indeed. their deregulation can directly lead to some of the hallma…
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