CORDIS Project
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This research investigates the role of histone modifying enzymes in regulating cellular metabolism. It focuses on how these enzymes influence the abundance of acetyl coenzyme A, linking epigenetic modifications to metabolic processes.
Accumulating evidence in recent years has highlighted strong regulatory interactions between epigenetic mechanisms and metabolic transformations, mainly through transcriptional control of key metabolic genes.
However, what has been overlooked is the direct effect of histone modifying enzymes on cellular metabolism as they are large consumers of sentinel metabolites.
Therefore, I hypothesize that histone modifying enzymes and their mediated post-translation modifications (PTMs) on histones direct…
UNIVERSITY OF CYPRUS
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