CORDIS Project
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This project investigates how metabolic signals from different tissues influence the characteristics and functions of Th17 cells, which play a role in autoimmune diseases like multiple sclerosis. By utilizing advanced techniques such as single-cell RNA sequencing and spatial RNA sequencing, the research aims to identif…
Autoimmune diseases affect an estimated 3-9% of the population and cause major personal and socio-economic consequences. IL-17-producing CD4+ T cells (Th17) are recruited to inflamed tissues and involved in autoimmune pathogenesis but were recently also shown to have homeostatic function in tissues.
Preliminary data from the outgoing host indicate that Th17 cells are transcriptionally distinct in different tissues.
How tissue Th17 cells acquire such specialized characteristics remains elusive. B…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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United States, Boston
Type: Research institute
Activity type: Research Organisations
SME: No
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