CORDIS Project
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This project investigates the role of apolipoproteins and lipoprotein modifying enzymes in obesity and insulin resistance. By studying genetic variations in mice, it aims to uncover mechanisms that contribute to metabolic syndrome and identify potential therapeutic targets.
Apolipoproteins and lipoprotein modifying enzymes are responsible for the maintenance of lipid homeostasis in the circulation.
Mutations in these proteins may affect the lipoproteins present in plasma and may result in dyslipidemia.
Obesity plays a central role in the development of the metabolic syndrome.
Our data indicate that apoE promotes diet-induced obesity.
Based on this, we hypothesize that components of the lipoprotein system that promote direct delivery of lipids to the peripheral tiss…
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