CORDIS Project
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This project explores the relationship between mitochondrial function and body weight regulation, investigating how mitochondrial defects can lead to obesity or thinness. It aims to identify metabolic pathways and potential therapeutic compounds for mitochondrial diseases and obesity.
This proposal aims to clarify mitochondrial contribution to obesity and thinness, using carefully characterized mitochondrial disease and obese patient materials, and genetically modified disease models.
Manifestations of mitochondrial respiratory chain (RC) defects range from infantile multisystem disorders to adult-onset myopathies or neurodegeneration, and even aging-related wasting.
Why defects in oxidative ATP production can lead to such variety of manifestations and tissue specificity is u…
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