CORDIS Project
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The MetaboSENS project explores the role of class 3 phosphoinositide 3-kinase in metabolic homeostasis and nutrient sensing. By investigating its regulatory functions and genetic alterations, the research aims to redefine our understanding of systemic metabolism and identify potential therapeutic targets for metabolic…
Nutrient sensing enables metabolic homeostasis by matching energy use with fuel availability.
The vast body of knowledge on pro-anabolic nutrient sensors, such as insulin and class 1 phosphoinositol-3 kinase (PI3K) signalling exposed the missing links in molecular coordination of catabolism.
The cellular catabolism relies on mitochondrial activities and on lysosomal pathway of autophagy, both paced by the biological clock.
However, how pro-catabolic nutrient sensors synchronize these catabolic a…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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