CORDIS Project
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This project investigates the role of the kinase NUAK1 in regulating mitochondrial metabolism during the development of neurons. By exploring its interaction with a novel substrate, the research aims to uncover new pathways that influence neuronal growth and function, particularly in the context of neurodevelopmental d…
Neurodevelopmental disorders (NDDs) affect 3-8 percent of children across Europe and cause a life-long alteration of cognitive abilities or social interactions with little therapeutic possibilities.
Recent studies have uncovered that dysfunctional mitochondria and metabolism are involved in NDDs like intellectual disability and autism spectrum disorder.
Notably, neuronal circuit development, a crucial process during the formation of the brain, is characterized by an increase in metabolic activit…
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