CORDIS Project
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This project investigates how certain genetic variations, known as metastable epialleles, are influenced by environmental factors and stress during early development. By studying the mechanisms of chromatin state regulation, the project aims to understand their role in gene expression and implications for diseases and…
Metastable epialleles are alleles that are variably expressed in genetically identical individuals.
These epialleles are established during early development by epigenetic modifications in a process influenced by stress and the environment.
The epiallele’s state can subsequently be maintained throughout development and adult life.
Studying the mechanisms underlying establishment and maintenance of chromatin states is critical to understanding how the environment can shape the epigenome and how i…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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