CORDIS Project
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This project investigates the role of the primary cilium in prostate cancer, focusing on how metabolic changes during low oxygen conditions affect cilia formation. It aims to identify key molecular interactions and potential drug targets to improve treatment strategies for aggressive prostate cancers.
The primary cilium (PC), a ubiquitous microtubule (MT)-based organelle that protrudes from the apical surface of most human cells, is essential for transducing signals required for growth control.
Many cancers, including prostate cancer, exhibit near- complete loss of cilia during the early stages of oncogenic transformation.
Novel strategies are urgently needed to treat the most aggressive and worst prognosis prostate cancers, the most common cancer and 2nd leading cause of cancer death for men…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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