CORDIS Project
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This project investigates the role of metabolic pathways in aging, focusing on how nutrient processing affects health in older individuals. By studying various models, it aims to identify genetic factors that enhance metabolic flexibility and promote healthy aging.
Aging has long been considered a passive process.
More recently studies have defined an important, active role for metabolic pathways in aging and age-related diseases. I have previously demonstrated a marked dysregulation of fat metabolism in aged mice that contributes to their overweight and glucose intolerance.
Here, I propose a model that links healthy aging to efficient processing of nutrients, a state termed metabolic flexibility: reducing protein or carbohydrate metabolism will strongly s…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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