CORDIS Project
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The project develops a new technique for the absolute quantification of proteins and peptides using a metal tagging method. This approach aims to improve the analysis of complex protein mixtures, particularly in bacterial proteomes and medical applications.
The quantitative analysis of protein mixtures is pivotal for the understanding of variations in the proteome of living systems.
Therefore, several approaches have been devised in recent years, which generally allow only the relative quantitative analysis of peptides and proteins.
We have presented proof of concept of a new MeCAT technique, which offers a quantitative determination of proteins and peptides. A macrocyclic metal chelate complex (DOTA) loaded with different lanthanides (Me(III)-ions…
HUMBOLDT-UNIVERSITAET ZU BERLIN
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