CORDIS Project
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This project investigates the relationship between toxic metal exposure and amyotrophic lateral sclerosis (ALS) by measuring heat shock proteins and metal levels in blood and urine samples. It aims to clarify the role of these factors in ALS progression and identify potential biomarkers.
Background:
Exposure to toxic metals are proposed as risk factors for amyotrophic lateral sclerosis (ALS).
Despite this, evidence remains mixed, with only evidence for lead exposure supported by recent meta-analysis.
Many studies neglected that biomarkers may be affected by kidney and liver function.
Additionally, the heat shock protein (HSP) response is triggered by toxic metal exposures, and there is evidence for altered HSP metabolism in ALS.
Methods:
Using available samples (105 ALS cases,…
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
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