CORDIS Project
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This project investigates how maternal epigenetic modifications influence embryonic metabolism in Drosophila. By studying the role of the MOF protein in acetylating histone proteins, the research aims to uncover the mechanisms by which maternal factors affect offspring development and metabolic regulation.
The risk of prenatal onset of metabolic disorders is influenced by the maternal environment, which is inherited by the offspring through epigenetic modifications.
Epigenetic modifications utilize metabolic substrates, highlighting the connection between epigenetics and metabolism.
In Drosophila, one key epigenetic modification is the MOF-mediated acetylation of histone H4 at lysine 16 (H4K16ac), which is known to be intergenerationally transmitted from mother to embryo.
This makes Drosophila an…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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