CORDIS Project
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This project examines the unique cardiac metabolism of naked mole-rats, focusing on adaptations to hypoxia. It aims to uncover genetic and metabolic features that contribute to their heart health and longevity, with potential implications for human heart disease.
The overarching aim of this proposal is to identify unique features of naked mole-rat cardiac metabolism that serve as advantageous adaptations to deal with a hypoxic environment, a state relevant to heart disease.
Coronary heart disease is a leading cause of death and its pathogenesis has been linked to metabolic abnormalities.
The naked mole–rat has recently emerged as a rodent model of interest to biomedicine due to its extraordinarily long and healthy lifespan (>36 years).
Naked mole-rats ex…
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