CORDIS Project
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This project explores how metabolism influences the growth of metastatic breast cancer by regulating collagen production. It aims to uncover the mechanisms behind this regulation and develop strategies to inhibit metastasis through metabolic targeting.
Metastatic growth of cancer cells requires extracellular matrix (ECM) production.
The current understanding is that transcription factors regulate ECM production and thus metastatic growth by increasing the expression of collagen prolyl 4-hydroxylase (CP4H).
In contrast, we recently discovered that metabolism regulates CP4H activity independently of the known transcription factors.
Specifically, we found that loss of pyruvate metabolism inhibits CP4H activity and consequently ECM–dependent breas…
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