CORDIS Project
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The MetD-AO project focuses on developing artificial organelles that mimic the enzyme S-adenosylmethionine synthetase to treat nonalcoholic fatty liver disease. By creating polymer nanoparticles that can deliver this enzyme effectively to liver cells, the project aims to restore cellular function and open new therapeut…
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the Western world, encompassing a spectrum of liver damage.
Multiple issues are involved on the cellular level in failing liver often including enzyme deficiencies such as reduced biosynthesis of S-adenosylmethionine (SAMe).
Preserving SAMe homeostasis has only recently started to be considered as a potential therapeutic target in liver-related medical conditions.
However, employing the required enzyme, SAMe syn…
AARHUS UNIVERSITET
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