CORDIS Project
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This project aims to understand the mechanisms that facilitate DNA replication at challenging genomic regions, particularly telomeres. By investigating the cellular responses to replication stress, it seeks to uncover factors that contribute to genome stability and cancer.
DNA replication is an essential process for genome duplication, cell division and ultimately organismal survival that ensures faithful transmission of the genome to progeny.
Certain genomic loci represent major obstacles to DNA replication including fragile sites, G-rich tracts and repetitive sequences, such as ribosomal DNA and telomeres.
Mammalian telomeres have the propensity to adopt complex DNA secondary structures, including telomere-loops and telomeric G-quadruplex DNA, which are believed…
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