CORDIS Project
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This project investigates how mutations in the TP53 gene affect cell metabolism and the epigenetic landscape during cancer development. It aims to uncover mechanisms linking metabolism and gene expression, potentially leading to new cancer treatment strategies.
Carcinogenesis is a multi-factorial disease which combines genetic mutations, aberrant epigenetic landscape and altered cell metabolism. TP53 which is the most mutated gene in human cancers, is known to regulate cell metabolism.
It has been recently established that the metabolic status of cells can modulate the epigenetic landscape.
The goal of this proposal is to characterize metabolic-driven modulation of epigenetic landscape during carcinogenesis using TP53 mutated cancers as models.
In this…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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