CORDIS Project
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This project investigates the role of DNA methylation and hydroxymethylation in distal regulatory elements during cancer progression. It aims to develop methods for analyzing these modifications to enhance understanding of their impact on gene expression and potential therapeutic targets in cancer treatment.
In carcinogenesis epigenetic aberrations occur early, are widespread across the genome and are potentially reversible. DNA methylation (5mC) at gene promoters and CpG islands (CGIs) is well recognized for affecting gene expression.
In contrast, little is known on the role of DNA methylation in distal regulatory elements (DREs).
Based on recent genome-wide studies, we hypothesize that DREs are more sensitive than CGIs to changes in DNA methylation, thus they may function as primary responders to…
THE UNIVERSITY OF BIRMINGHAM
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