CORDIS Project
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This project explores the roles of DNA methylation across diverse eukaryotic organisms, aiming to understand its evolutionary significance. By employing advanced genomic techniques, it seeks to clarify how DNA methylation influences gene regulation and transposable element silencing in various life forms.
Cytosine DNA methylation is a major component of eukaryotic chromatin, yet extensive variation of methylation patterns occurs throughout eukaryotes.
So far, the roles of DNA methylation have been mostly characterized in vertebrates, plants and fungi, where two common patterns have emerged as potentially ancestral within eukaryotes: methylation of silent transposable elements and methylation of constitutively transcribed genes (gene body methylation).
However, the genes responsible for depositing…
QUEEN MARY UNIVERSITY OF LONDON
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