CORDIS Project
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This project investigates the structure and function of the tripartite attachment complex in Trypanosoma brucei, a parasite causing African sleeping sickness. It aims to identify the components of this complex and explore its potential as a target for new treatments.
Kinetoplastid flagellates of the Trypanosoma brucei are widely distributed, causing human African trypanosomiasis and animal trypanosomiasis, listed among major tropical diseases by WHO. T. brucei possesses a single flagellum and a single mitochondrion containing kinetoplast (highly constructed mitochondrial DNA and related proteins).
Tripartite attachment complex (TAC), a highly organized cytoskeletal structure with timed remodeling, was found to link between the kinetoplast and the flagellum b…
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